CD12681
CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC50 of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively. CD12681 decreases the IL-17 inflammatory cell recruitment. CD12681 has the potential for the research of psoriasis[1].
Product Specifications
CAS Number
1952239-59-6
UNSPSC
12352005
Target
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cd12681.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(NC(N2CC3CCOCC3)=O)=C2C=C1)(N(C4=CC=C(C)C=C4C)CC(C)C)=O
Molecular Formula
C25H33N3O4S
Molecular Weight
471.61
References & Citations
[1]Ouvry G, et al. Discovery and Characterization of CD12681, a Potent RORγ Inverse Agonist, Preclinical Candidate for the Topical Treatment of Psoriasis. ChemMedChem. 2018 Feb 20;13 (4) :321-337.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORγ
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