CHIC35

CHIC35, an analog of EX-527, is a potent and selective inhibitor of SIRT1 (IC50=0.124 μM) . CHIC35 shows potential selective inhibition against SIRT1 over SIRT2 (IC50=2.8 μM) or SIRT3 (IC50>100 μM) [1]. CHIC35 has anti-inflammatory effects and can be used for CHARGE syndrome research[1][2].

Product Specifications

CAS Number

848193-72-6

UNSPSC

12352005

Hazard Statement

H301-H315-H319-H335

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chic35.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1CCCCC2=C1NC3=C2C=C(Cl)C=C3)N

Molecular Formula

C14H15ClN2O

Molecular Weight

262.73

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Jérôme Lugrin, et al. The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock. Biochim Biophys Acta. 2013 Jun;1833 (6) :1498-510|[2]Zainab Asad, et al. Chemical screens in a zebrafish model of CHARGE syndrome identifies small molecules that ameliorate disease-like phenotypes in embryo. Eur J Med Genet. 2020 Feb;63 (2) :103661.