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AJ-76

AJ-76 ((+) -AJ 76; (1S,2R) -AJ 76) is a dopamine autoreceptor antagonist. AJ-76 can increase the synthesis and turnover of dopamine in the rat brain, while having little effect on the synthesis and turnover of serotonin (5-HT) and norepinephrine. AJ-76 can also antagonize the sedative effects of low-dose apomorphine and has a weak antagonistic effect on postsynaptic dopamine receptor[1].

Product Specifications

CAS Number

85379-09-5

Product Name Alternative

(+) -AJ 76; (1S,2R) -AJ 76

UNSPSC

12352005

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aj-76.html

Solubility

10 mM in DMSO

Smiles

CCCN[C@H]1[C@@H](C)C2=C(C(OC)=CC=C2)CC1

Molecular Formula

C15H23NO

Molecular Weight

233.35

References & Citations

[1]Svensson K, et al. (+) -AJ 76 and (+) -UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch Pharmacol. 1986 Nov;334 (3) :234-45.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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