GSK317354A
GSK317354A is a ROCK and GRK inhibitor. GSK317354A can be used for heart failure and Parkinson’s disease research[1].
Product Specifications
CAS Number
874119-13-8
UNSPSC
12352005
Target
G Protein-coupled Receptor Kinase (GRK) ; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/gsk317354a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(C2=CC=C(C(F)(F)F)N=C2)=NC1C3=CC=C(F)C=C3)NC4=CC5=C(NN=C5)C=C4
Molecular Formula
C25H18F4N6O
Molecular Weight
494.44
References & Citations
[1]Homan KT, et al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10 (1) :310-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK
Frequently Asked Questions
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