Neocarzinostatin
Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs) . Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2].
Product Specifications
CAS Number
9014-02-2
Product Name Alternative
Zinostatin; Vinostatin
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/neocarzinostatin.html
Concentration
0.5 mg/mL * 200 μL in 20 mM MES buffer pH=5.5
Purity
99.9
Solubility
10 mM in DMSO
Smiles
[Neocarzinostatin]
References & Citations
[1]Athyala PK, et al. Probing the biophysical interaction between Neocarzinostatin toxin and EpCAM RNA aptamer. Biochem Biophys Res Commun. 2016 Jan 8;469 (2) :257-62.|[2]Allen Taylor, et al. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene (2002) 21, 4363- 4373.|[3]Athyala PK, et al. Neocarzinostatin, Aptamer Conjugates for Targeting EpCAM-positive Tumor Cells. Anticancer Res. 2017 Jul;37 (7) :3615-3629.|[4]Tianqin G, et al. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biol Pharm Bull. 2016 Oct 1;39 (10) :1623-1630.|[5]Rogers D, et al. Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Launched
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