Neocarzinostatin

Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs) . Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment [1][2].

Product Specifications

CAS Number

[9014-02-2]

Product Name Alternative

Zinostatin; Vinostatin

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/neocarzinostatin.html

Concentration

0.5 mg/mL * 200 μL in 20 mM MES buffer pH=5.5

Purity

99.9

Solubility

10 mM in DMSO

Smiles

[Neocarzinostatin]

References & Citations

[1]Athyala PK, et al. Probing the biophysical interaction between Neocarzinostatin toxin and EpCAM RNA aptamer. Biochem Biophys Res Commun. 2016 Jan 8;469 (2) :257-62.|[2]Allen Taylor, et al. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene (2002) 21, 4363- 4373.|[3]Athyala PK, et al. Neocarzinostatin, Aptamer Conjugates for Targeting EpCAM-positive Tumor Cells. Anticancer Res. 2017 Jul;37 (7) :3615-3629.|[4]Tianqin G, et al. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biol Pharm Bull. 2016 Oct 1;39 (10) :1623-1630.|[5]Rogers D, et al. Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy.