Inotilone

Inotilone is an inhibitor of matrix metalloproteinase MMP-2 and MMP-9, to against metastatic in lung cancer cells. Inotilone enhances the activity of the antioxidant enzymes to support its anti-metastatic activity. Inotilone also inhibits IκBα phosphorylation and NFκB p65 nuclear translocation, involving in FAK, PI3K/AKT, MAPKs and NFκB pathways[1].

Product Specifications

CAS Number

[906366-79-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MMP; NF-κB

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/inotilone.html

Solubility

10 mM in DMSO

Smiles

O=C1/C(OC(C)=C1)=C/C2=CC=C(O)C(O)=C2

Molecular Formula

C12H10O4

Molecular Weight

218.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Chao W, et al. Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. Sci Rep. 2019 Feb 20;9 (1) :2344.