Methapyrilene

Methapyrilene is a histamine antagonist, a pyridine chemical with anticholinergic activity. Methapyrilene can cause target organ-specific epigenetic alterations, such as a decrease in DNA methylation levels. Methapyrilene induces hepatocellular carcinoma in rats[1][2].

Product Specifications

CAS Number

[91-80-5]

UNSPSC

12352005

Hazard Statement

H301

Target

Histamine Receptor; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/methapyrilene.html

Purity

99.66

Solubility

10 mM in DMSO

Smiles

CN(C)CCN(C1=NC=CC=C1)CC2=CC=CS2

Molecular Formula

C14H19N3S

Molecular Weight

261.39

Precautions

H301

References & Citations

[1]Volodymyr Tryndyak, et al. Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223.|[2]Andrew Craig, et al. Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat. J Proteome Res. 2006 Jul;5 (7) :1586-60