AZD-7295

AZD-7295 is a HCV NS5A protein inhibitor, with an EC50 of 7 nM for GT-1b replicon[1][2].

Product Specifications

CAS Number

[929890-64-2]

UNSPSC

12352005

Target

HCV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/azd-7295.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(C2=CC(NC(C3CC3)=O)=CC=C2OC(F)(F)F)C=C1)NC4=CC=C(CN5CCN(S(=O)(CCC)=O)CC5)C=C4

Molecular Formula

C32H35F3N4O5S

Molecular Weight

644.70

References & Citations

[1]Erik De Clercq, et al. Current race in the development of DAAs (direct-acting antivirals) against HCV. Biochem Pharmacol. 2014 Jun 15;89 (4) :441-52.|[2]Min Gao, et al. Antiviral activity and resistance of HCV NS5A replication complex inhibitors. Curr Opin Virol. 2013 Oct;3 (5) :514-20.