AMG0347
AMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm) [1].
Product Specifications
CAS Number
946615-43-6
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/amg0347.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C2CC(O)CCC2=CC=C1)/C=C/C3=CC=C(C(F)(F)F)N=C3N4CCCCC4
Molecular Formula
C24H26F3N3O2
Molecular Weight
445.48
References & Citations
[1]Chaoran Wu, et al. Effect of AMG0347, a Transient Receptor Potential Type V1 Receptor Antagonist, and Morphine on Pain Behavior after Plantar Incision。Anesthesiology. 2008 Jun;108 (6) :1100-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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