Trimidox
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC50 of 35 μM[1].
Product Specifications
CAS Number
95933-74-7
Product Name Alternative
VF-233
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trimidox.html
Solubility
10 mM in DMSO
Smiles
N=C(C1=CC(O)=C(O)C(O)=C1)NO
Molecular Formula
C7H8N2O4
Molecular Weight
184.15
References & Citations
[1]T Szekeres, et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood. 1994 Dec 15;84 (12) :4316-21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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