Razaxaban (hydrochloride)

Razaxaban hydrochloride (BMS 561389 hydrochloride) is a highly potent, selective and orally active factor Xa inhibitor with a Ki of 0.19 nM. Razaxaban hydrochloride exhibits excellent selectivity (>5000-fold) for factor Xa over other related serine proteases. Razaxaban hydrochloride is also a potent thrombin inhibitor with a Ki of 540 nM. Razaxaban hydrochloride has strongly antithrombotic activity[1].

Product Specifications

CAS Number

405940-76-3

Product Name Alternative

BMS 561389 (hydrochloride) ; DPC 906 (hydrochloride)

UNSPSC

12352005

Target

Factor Xa; Thrombin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/razaxaban-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC(C(F)(F)F)=NN1C2=CC3=C(ON=C3N)C=C2)NC4=CC=C(N5C=CN=C5CN(C)C)C=C4F.[H]Cl

Molecular Formula

C24H21ClF4N8O2

Molecular Weight

564.92

References & Citations

[1]Quan ML, et al. Discovery of 1- (3'-aminobenzisoxazol-5'-yl) -3-trifluoromethyl-N-[2-fluoro-4- [ (2'-dimethylaminomethyl) imidazol-1-yl]phenyl]-1H-pyrazole-5-carboxyamide hydrochloride (razaxaban), a highly potent, selective, and orally bioavailable factor Xa inhibitor. J Med Chem. 2005 Mar 24;48 (6) :1729-44.