DPC423
DPC423 is a selective and orally active factor Xa inhibitor with a Kis of 0.15 (human) and 0.3 (rabbit) nM. DPC423 exhibits Kis of 60, 61 and 6000 nM against human trypsin, plasma kallikrein and thrombin. DPC423 blocks the formation of prothrombinase complex, reduces thrombin production, inhibits fibrin formation and platelet activation. DPC423 can be used for the study of anticoagulation of arterial thrombosis[1][2].
Product Specifications
CAS Number
292135-59-2
UNSPSC
12352005
Target
Factor Xa; Kallikrein; Ser/Thr Protease; Thrombin
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dpc423.html
Solubility
10 mM in DMSO
Smiles
NCC1=CC(N2C(C(NC3=CC=C(C4=CC=CC=C4S(=O)(C)=O)C=C3F)=O)=CC(C(F)(F)F)=N2)=CC=C1.Cl
Molecular Formula
C25H21ClF4N4O3S
Molecular Weight
568.97
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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