Trap-101 (hydrochloride)

Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors over classical opioid receptors. Trap-101 stimulates GTPγ35S binding to CHOhNOP membranes with pKi values of 8.65, 6.60, 6.14 and [1].

Product Specifications

CAS Number

[1216621-00-9]

UNSPSC

12352005

Hazard Statement

H301

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trap-101-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1N(CC)C2=CC=CC=C2N1C3=C(CO)CN(CC4CCCCCCC4)CC3.[H]Cl

Molecular Formula

C24H36ClN3O2

Molecular Weight

434.01

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]Matteo Marti, et al. The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA. J Neurochem. 2008 Dec;107 (6) :1683-96.