ISOX-DUAL

1962928-22-8

ISOX-DUAL is a dual CBP/BRD4 inhibitor with IC50 values of 0.65 μM and 1.5 μM for CBP and BRD4, respectively[1].

Epigenetic Reader Domain

Reference compound

Epigenetics

Others

https://www.medchemexpress.com/isox-dual.html

10 mM in DMSO

CC1=C(C2=CC3=C(C=C2)N(CCN4CCOCC4)C(CCC5=CC=C(C=C5)OCCCN(C)C)=N3)C(C)=NO1

531.69

[1]Edmonds AK, et, al. Scale-up and optimization of the synthesis of dual CBP/BRD4 inhibitor ISOX-DUAL. Org Biomol Chem. 2022 May 18;20(19):4021-4029.

Room temperature

No Development Reported