WAY-181187 (oxalate)
WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2].
Product Specifications
CAS Number
1883548-85-3
Product Name Alternative
SAX-187 (oxalate)
UNSPSC
12352209
Target
5-HT Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/way-181187-oxalate.html
Solubility
10 mM in DMSO
Smiles
O=C(C(O)=O)O.O=S(C1=C(N=C2SC=CN21)Cl)(N3C=C(CCN)C4=C3C=CC=C4)=O
Molecular Formula
C17H15ClN4O6S2
Molecular Weight
470.91
References & Citations
[1]Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33 (6) :1323-35.|[2]Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661 (1-3) :8-14.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
5-HT6 Receptor; MUC2
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