WAY-181187 (oxalate)

WAY-181187 (SAX-187) oxalate is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY-181187 oxalate mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist[1][2].

Product Specifications

CAS Number

[1883548-85-3]

Product Name Alternative

SAX-187 (oxalate)

UNSPSC

12352209

Target

5-HT Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/way-181187-oxalate.html

Solubility

10 mM in DMSO

Smiles

O=C(C(O)=O)O.O=S(C1=C(N=C2SC=CN21)Cl)(N3C=C(CCN)C4=C3C=CC=C4)=O

Molecular Formula

C17H15ClN4O6S2

Molecular Weight

470.91

References & Citations

[1]Lee E Schechter, et al. Neuropharmacological Profile of Novel and Selective 5-HT6 Receptor Agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33 (6) :1323-35.|[2]Teresa Riccioni, et al. ST1936 Stimulates cAMP, Ca2+, ERK1/2 and Fyn Kinase Through a Full Activation of Cloned Human 5-HT6 Receptors. Eur J Pharmacol. 2011 Jul 1;661 (1-3) :8-14.