Icerguastat (Carbonate)
Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A) . Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3].
Product Specifications
CAS Number
[1883549-35-6]
Product Name Alternative
Sephin1 (Carbonate) ; IFB-088 (Carbonate)
UNSPSC
12352005
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/icerguastat-carbonate.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C=CC=C1)/C=N/NC(N)=N.OC(O)=O
Molecular Formula
C9H11ClN4O3
Molecular Weight
258.66
References & Citations
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-110365/Icerguastat-Carbonate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-110365/
Scientific Category
Reference compound1
Clinical Information
Phase 2
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