Icerguastat (Carbonate)

Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A) . Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect[1][2][3].

Product Specifications

CAS Number

[1883549-35-6]

Product Name Alternative

Sephin1 (Carbonate) ; IFB-088 (Carbonate)

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/icerguastat-carbonate.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(C=CC=C1)/C=N/NC(N)=N.OC(O)=O

Molecular Formula

C9H11ClN4O3

Molecular Weight

258.66

References & Citations

[1]Chen Y, et al. Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain. 2019;142 (2) :344-361.|[2]Thapa S, et al. Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model. Mol Neurobiol. 2020;57 (5) :2206-2219.|[3]Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348 (6231) :239-242.