CCT241533 (dihydrochloride)
CCT241533 dihydrochloride is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM[1].
Product Specifications
CAS Number
1962925-28-5
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cct241533-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(C2=NC3=CC(OC)=C(C=C3C(N[C@H]4[C@@H](CNC4)C(O)(C)C)=N2)OC)=C(C=C1)O.Cl.Cl
Molecular Formula
C23H29Cl2FN4O4
Molecular Weight
515.41
References & Citations
[1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71 (2) :463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2- (quinazolin-2-yl) phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54 (2) :580-90.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2
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