PKI-166 (hydrochloride)
PKI-166 hydrochloride is a potent, selective and orally active EGFR tyrosine kinase inhibitor, with an IC50 of 0.7 nM[1].
Product Specifications
CAS Number
2230253-82-2
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pki-166-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C2=CC3=C(N=CN=C3N2)N[C@H](C)C4=CC=CC=C4)C=C1.Cl[H]
Molecular Formula
C20H19ClN4O
Molecular Weight
366.84
References & Citations
[1]Bruns CJ, et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 2000 Jun 1;60 (11) :2926-35.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
IMSIGG2AKICC1184CER78025UG 25 µg
Mouse IgG2a Kappa Isotype Control Monoclonal Clone C1184 ER780 25ug
Sign In for Pricing
View Details 22516121 3x 1.0µg DNA
GPR15 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details 44173114 3x 1.0 µg
Slc38a6 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
Sign In for Pricing
View Details 
MBS6293896-01 0.2 mL
DVL1, ID (DVL1, Segment polarity protein dishevelled homolog DVL-1, DSH homolog 1) (APC)
Sign In for Pricing
View Details