SPL-334
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1].
Product Specifications
CAS Number
[688347-51-5]
UNSPSC
12352005
Target
GSNOR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/spl-334.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(CSC2=NC3=C(C(N2CC4=CC=C(C(O)=O)C=C4)=O)SC=C3)C=CC=C1
Molecular Formula
C22H15N3O3S2
Molecular Weight
433.50
References & Citations
[1]Ferrini ME, et, al. S-nitrosoglutathione reductase inhibition regulates allergen-induced lung inflammation and airway hyperreactivity. PLoS One. 2013 Jul 25;8 (7) :e70351.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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