MI-192

MI-192 is a selective HDAC2 and HDAC3 inhibitor with IC50s of 30 nM and 16 nM, respectively. MI-192 is more selective for HDAC2/3 than other HDAC isomers.MI-192 induces myeloid leukaemic cells apoptosis. Anticaner and neuroprotective activities[1][2].

Product Specifications

CAS Number

[1415340-63-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mi-192.html

Purity

99.9

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

O=C1C2=CC=CC=C2C(CN1CC3=CC=C(C(NC4=C(C=CC=C4)N)=O)C=C3)=C

Molecular Formula

C24H21N3O2

Molecular Weight

383.44

Precautions

H302, H315, H319, H335

References & Citations

[1]Marjorie Boissinot, et al. Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk Res. 2012 Oct;36 (10) :1304-10.|[2]S V Demyanenko, et al. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020 Jan;57 (1) :239-248.