Flupirtine-d4 (hydrochloride)

Flupirtine-d4 (D 9998-d4) hydrochloride is the deuterium labeled Flupirtine. Flupirtine (D 9998) hydrochloride is a selective neuronal potassium channel opener that also has NMDA receptor antagonist properties[1][2].

Product Specifications

CAS Number

[1324717-75-0]

Product Name Alternative

D 9998-d4 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

IGluR; Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

Cl[H].CCOC(NC1=C(N=C(NCC2=C([2H])C([2H])=C(F)C([2H])=C2[2H])C=C1)N)=O

Molecular Formula

C15H14D4ClFN4O2

Molecular Weight

344.81

Precautions

P264-P270-P330-P501

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Kornhuber J, et al. Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltageindependent potassium channels. Rapid communication. J Neural Transm. 1999;106 (9-10) :857-67.; Klinger F, et al. Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. Br J Pharmacol. 2012 Jul;166 (5) :1631-42.; Swedberg MD, et al. Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. J Pharmacol Exp Ther. 1988 Sep;246 (3) :1067-74.; Wu SN, et al. Evidence for inhibitory effects of flupirtine, a centrally acting analgesic, on delayed rectifier k (+) currents in motor neuron-like cells. Evid Based Complement Alternat Med. 2012;2012:148403.; Kolosov A, et al. Flupirtine enhances the anti-hyperalgesic effects of morphine in a rat model of prostate bone metastasis. Pain Med. 2012 Nov;13 (11) :1444-56.; Michel MC, et al. Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. Br J Clin Pharmacol. 2012 May;73 (5) :821-5.