MRS5698

MRS5698 is a selective Gi protein-coupled A3 adenosine receptor (A3AR) agonist, with Kis of approximately 3 nM for human and mouse A3AR, respectively. MRS5698 can be used for the research of pain and psoriasis[1][2].

Product Specifications

CAS Number

1377273-00-1

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mrs5698.html

Solubility

10 mM in DMSO

Smiles

CNC([C@]12[C@]([C@](N3C4=NC(C#CC5=CC(F)=C(C=C5)F)=NC(NCC6=CC(Cl)=CC=C6)=C4N=C3)([H])[C@@H]([C@@H]2O)O)([H])C1)=O

Molecular Formula

C28H23ClF2N6O3

Molecular Weight

564.97

References & Citations

[1]Tosh DK, et al. Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A3 adenosine receptor agonist that protects against chronic neuropathic pain. Purinergic Signal. 2015;11 (3) :371-387.|[2]Wahlman C, et al. Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms. Pain. 2018;159 (6) :1025-1034.|[3]López-Cano M, et al. Optical control of adenosine A3 receptor function in psoriasis. Pharmacol Res. 2021 Aug;170:105731.