PQ-69
PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a Ki value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (Ki=208 nM) and >1,000-fold selectivity over hA3 receptor (Ki >100 μM) . PQ-69 can be used for the research of renal dysfunction[1].
Product Specifications
CAS Number
910045-32-8
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pq-69.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=CC(F)=C2)NC3=C1C(NCCCC)=NC4=CC=CC=C34
Molecular Formula
C20H19FN4O
Molecular Weight
350.39
References & Citations
[1]Min Lu, et al. PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 2014 Dec;10 (4) :619-29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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