PDI-IN-1

PDI-IN-1 (Compound P1) is a cell-permeable human protein disulfide isomerase (PDI) inhibitor with an IC50 of 1.7 μM. PDI-IN-1 has anti-cancer activity.

Product Specifications

CAS Number

[1461648-55-4]

UNSPSC

12352005

Target

PDI

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pdi-in-1.html

Solubility

10 mM in DMSO

Smiles

C=CS(OC(C=C1)=CC=C1C[C@@H](C(NCCCC#C)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC2=CC=CC=C2)=O)(=O)=O

Molecular Formula

C30H37N3O7S

Molecular Weight

583.70

References & Citations

[1]Ge J, Zhang C J, et al. Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase[J]. ACS chemical biology, 2013, 8 (11) : 2577-2585.