XAP044

XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms[1].

Product Specifications

CAS Number

[196928-50-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/xap044.html

Purity

99.99

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C1C2=CC=C(O)C=C2OC=C1OC3=CC=C(I)C=C3

Molecular Formula

C15H9IO4

Molecular Weight

380.13

Precautions

H302, H315, H319, H335

References & Citations

[1]Gee CE, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. J Biol Chem. 2014;289 (16) :10975-10987.