S07662
S07662 is a human constitutive androstane receptor (hCAR) inhibitor with an IC50 of 0.7 μM. S07662 recruits the corepressor NCoR in cell-based assays and attenuate the expression of CYP2B6 mRNA in human primary hepatocytes induced by phenytoin and CITCO (HY-103244).
Product Specifications
CAS Number
883226-64-0
UNSPSC
12352005
Target
Constitutive Androstane Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/s07662.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=C(C)OC2=C1C=CC=C2)NCC3=CC=CS3
Molecular Formula
C16H16N2O2S
Molecular Weight
300.38
References & Citations
[1]Küblbeck J, et al. New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists. Mol Pharm. 2011 Dec 5;8 (6) :2424-33.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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