Gue1654
Gue1654 is a modulator of OXE-R. Gue1654 inhibits Gβγ but not Gα signaling triggered upon activation of Gα (i) -βγ by the chemoattractant receptor OXE-R. Gue1654 does not interfere nonspecifically with signaling directly at or downstream of Gβγ[1].
Product Specifications
CAS Number
[397290-30-1]
UNSPSC
12352005
Hazard Statement
H302
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gue1654.html
Purity
98.31
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(C(C1=CC=CC=C1)C2=CC=CC=C2)NC3=NC4=C(S3)C5=C(N=C(SC)S5)C=C4
Molecular Formula
C23H17N3OS3
Molecular Weight
447.60
Precautions
P264-P270-P330-P501
References & Citations
[1]Blättermann S, et al. A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer. Nat Chem Biol. 2012;8 (7) :631-638.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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