VU0463271 (quarterhydrate)

VU0463271 quarterhydrate is a potent KCC2 antagonist, with an IC50 of 61 nM[1].

Product Specifications

UNSPSC

12352005

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vu0463271-quarterhydrate.html

Purity

98.05

Solubility

DMSO : 19 mg/mL (ultrasonic; warming)

Smiles

O=C(N(C1CC1)C2=NC(C)=CS2)CSC3=NN=C(C4=CC=CC=C4)C=C3.[1/4].O

Molecular Formula

C19H18N4OS2.1/4H2O

Molecular Weight

387.00

References & Citations

[1]Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22 (14) :4532-5.|[2]Rui Chen, et al. Functional Coupling of K +-Cl - Cotransporter (KCC) to GABA-Gated Cl - Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. 2019 Jun 19;10 (6) :2765-2776.