VU590 (dihydrochloride)

VU590 dihydrochloride is a potent and moderately selective ROMK (Kir1.1) inhibitor, with an IC50 of 290 nM. VU590 also inhibits Kir7.1, with an IC50 of 8 μM. VU590 dihydrochloride is not a good probe of ROMK function in the kidney[1][2].

Product Specifications

CAS Number

[1783987-83-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/vu590-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=[N+](C1=CC=C(CN2CCOCCOCCN(CCOCC2)CC3=CC=C([N+]([O-])=O)C=C3)C=C1)[O-].Cl.Cl

Molecular Formula

C24H34Cl2N4O7

Molecular Weight

561.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79 (1) :42-50. |[2]Kharade SV, et al. Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590. Mol Pharmacol. 2017 Sep;92 (3) :338-346.