TWS119 (TFA)

TWS119 TFA is a specific inhibitor of GSK-3β, with an IC50 of 30 nM, and activates the wnt/β-catenin pathway.

Product Specifications

CAS Number

[1507095-58-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Others; Wnt

Type

Reference compound

Related Pathways

Others; Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tws119-tfa.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=CC(OC2=C3C(NC(C4=CC=CC(N)=C4)=C3)=NC=N2)=C1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C22H16F6N4O6

Molecular Weight

546.38

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104 (36) :14190-6.|[2]Hochstrasser RM. Two-dimensional spectroscopy at infrared and optical frequencies. Proc Natl Acad Sci U S A. 2007 Sep 4;104 (36) :14190-6.