APcK110

APcK110 is a potent Kit inhibitor that can be used for the research of acute myeloid leukemia (AML) . APcK110 induces AML cell apoptosis[1].

Product Specifications

CAS Number

1001083-74-4

UNSPSC

12352005

Target

C-Kit

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apck110.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C2=NNC3=NC(C4=CC(OC)=CC(OC)=C4)=CC=C23)C=C1

Molecular Formula

C20H16FN3O2

Molecular Weight

349.36

References & Citations

[1]Faderl S, et al. Kit inhibitor APcK110 induces apoptosis and inhibits proliferation of acute myeloid leukemia cells. Cancer Res. 2009 May 1;69 (9) :3910-7.|[2]Faderl S, et al. Kit inhibitor APcK110 extends survival in an AML xenograft mouse model. Invest New Drugs. 2011 Oct;29 (5) :1094-7.