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Tandospirone (hydrochloride)

Tandospirone (SM-3997) hydrochloride is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone hydrochloride has anxiolytic and antidepressant activities. Tandospirone hydrochloride can be used for the research of the central nervous system disorders and the underlying mechanisms[1][2][3].

Product Specifications

CAS Number

99095-10-0

Product Name Alternative

SM-3997 (hydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tandospirone-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@]2([H])[C@](C(N1CCCCN3CCN(C4=NC=CC=N4)CC3)=O)([H])[C@H]5C[C@@H]2CC5.Cl

Molecular Formula

C21H30ClN5O2

Molecular Weight

419.95

References & Citations

[1]Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28 (2) :99-109.|[2]Xuefei Huang, et al. Role of tandospirone, a 5-HT1A receptor partial agonist, in the treatment of central nervous system disorders and the underlying mechanisms. Oncotarget. 2017 Nov 24; 8 (60) : 102705–102720.|[3]Kyoko Nishitsuji, et al. The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress. Eur Neuropsychopharmacol. 2006 Jul;16 (5) :376-82.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 4

Isoform

5-HT1 Receptor; mLAG-3

Available Sizes

Frequently Asked Questions

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