Lamotrigine (isethionate)

Lamotrigine (BW430C) isethionate is a potent and orally active anticonvulsant or antiepileptic agent. Lamotrigine isethionate selectively blocks voltage-gated Na+ channels, stabilizing presynaptic neuronal membranes and inhibiting glutamate release. Lamotrigine isethionate can be used for the research of epilepsy, focal seizure, et al[1][2].

Product Specifications

CAS Number

[113170-86-8]

Product Name Alternative

LTG (isethionate) ; BW430C (isethionate)

UNSPSC

12352005

Hazard Statement

H301

Target

Autophagy; Sodium Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/lamotrigine-isethionate.html

Solubility

10 mM in DMSO

Smiles

O=S(O)(CCO)=O.ClC1=C(Cl)C(C2=C(N)N=C(N)N=N2)=CC=C1

Molecular Formula

C11H13Cl2N5O4S

Molecular Weight

382.22

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]M J Leach, et al. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. Sep-Oct 1986;27 (5) :490-7.|[2]Damianka P Getova, et al. A study of the effects of lamotrigine on mice using two convulsive tests. Folia Med (Plovdiv) . Apr-Jun 2011;53 (2) :57-62.