Fenoldopam (hydrochloride)

Fenoldopam (SKF 82526) hydrochloride is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM) . Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].

Product Specifications

CAS Number

[181217-39-0]

Product Name Alternative

SKF 82526 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Apoptosis; Dopamine Receptor; Histone Demethylase

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics; GPCR/G Protein; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/fenoldopam-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

ClC1=C(CCNCC2C3=CC=C(C=C3)O)C2=CC(O)=C1O.Cl

Molecular Formula

C16H17Cl2NO3

Molecular Weight

342.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258 (1) :193-8.|[2]Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561.|[3]Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.