(S) -WAY 100135 (dihydrochloride)
(S) -WAY 100135 dihydrochloride is a highly selective and potent antagonist of 5-HT 1A (IC50=33.9 nM) . (S) -WAY 100135 dihydrochloride has anxiolytic activity in animal models[1].
Product Specifications
CAS Number
149007-54-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-way-100135-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
COC1=C(N2CCN(CC2)C[C@H](C3=CC=CC=C3)C(NC(C)(C)C)=O)C=CC=C1.Cl.Cl
Molecular Formula
C24H35Cl2N3O2
Molecular Weight
468.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Cliffe IA, et al. (S) -N-tert-butyl-3- (4- (2-methoxyphenyl) -piperazin-1-yl) -2-phenylpropanamide [ (S) -WAY-100135]: a selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. J Med Chem. 1993 May 14;36 (10) :1509-10.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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