Pomalidomide-d4

Pomalidomide-d4 is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors<

Product Specifications

CAS Number

[1416575-78-4]

Product Name Alternative

CC-4047-d4

UNSPSC

12352005

Hazard Statement

H360

Target

Apoptosis; Isotope-Labeled Compounds; Ligands for E3 Ligase; Molecular Glues

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Others; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

96.38

Solubility

10 mM in DMSO

Smiles

O=C1N(C2C(NC(C([2H])([2H])C2([2H])[2H])=O)=O)C(C3=C(N)C=CC=C31)=O

Molecular Formula

C13H7D4N3O4

Molecular Weight

277.27

Precautions

H360

References & Citations

[1]Zhu YX, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.; Hernandez-Ilizaliturri FJ1, et al. Immunomodulatory drug CC-5013 or CC-4047 a|[2]Hernandez-Ilizaliturri FJ, et al. Immunomodulatory drug CC-5013 or CC-4047 and rituximab enhance antitumor activity in a severe combined immunodeficient mouse lymphoma model. Clin Cancer Res. 2005 Aug 15;11 (16) :5984-92.|[3]Yuan Xiao Zhu, et al. Molecular mechanism of action of the immune-modulatory drugs, thalidomide, lenalidomide and pomalidomide in multiple myeloma. Leuk Lymphoma. 2013 Apr;54 (4) :683-7.; Hernandez-Ilizaliturri FJ1