Crisaborole-d4
Crisaborole-d4 is deuterium labeled Crisaborole. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC50 of 0.49 μM.
Product Specifications
CAS Number
2268785-42-6
Product Name Alternative
AN-2728-d4; PF-06930164-d4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
N#CC1=C([2H])C([2H])=C(OC2=CC=C(B(O)OC3)C3=C2)C([2H])=C1[2H]
Molecular Formula
C14H6D4BNO3
Molecular Weight
255.07
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Akama T, et al. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis. Bioorg Med Chem Lett. 2009 Apr 15;19 (8) :2129-32.|[3]Nazarian R, et al. AN-2728, a PDE4 inhibitor for the potential topical treatment of psoriasis and atopic dermatitis. Curr Opin Investig Drugs. 2009 Nov;10 (11) :1236-42.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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