(R)-Gyramide A (hydrochloride)
Product Specifications
UNSPSC Description
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R)-Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM). (R)-Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.
Target Antigen
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/r-gyramide-a-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl
Molecular Weight
442.98
References & Citations
[1]Foss MH, et al. N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors. ACS Med Chem Lett. 2011 Apr 14;2(4):289-292.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-109785A/R-Gyramide-A-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-109785A/
Clinical Information
No Development Reported
CAS Number
1793050-70-0
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