(R) -Gyramide A (hydrochloride)

(R) -Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that disrupts supercoiling activity with an IC50 value of 3.3 µM. (R) -Gyramide A hydrochloride demonstrates antibacterial activity against E. coli, P. aeruginosa, and S. enterica (MICs of 10-80 µM) . (R) -Gyramide A hydrochloride does not affect the closely related enzyme topoisomerase IV.

Product Specifications

CAS Number

[1793050-70-0]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/r-gyramide-a-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC(F)=CC=C1C)(N[C@H]2CN(CC3=CC=C(OC(C)C)C=C3)CC2)=O.[H]Cl

Molecular Formula

C21H28ClFN2O3S

Molecular Weight

442.98

References & Citations

[1]Foss MH, et al. N-Benzyl-3-sulfonamidopyrrolidines are a New Class of Bacterial DNA Gyrase Inhibitors. ACS Med Chem Lett. 2011 Apr 14;2 (4) :289-292.