Alisertib (sodium)
Alisertib (MLN 8237) sodium is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib sodium induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity[1][2][3].
Product Specifications
CAS Number
1028486-06-7
Product Name Alternative
MLN 8237 (sodium)
UNSPSC
12352005
Target
Apoptosis; Aurora Kinase; Autophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alisertib-sodium.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O[Na]
Molecular Formula
C27H19ClFN4NaO4
Molecular Weight
540.91
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Aurora A; Aurora B
Frequently Asked Questions
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