Imidaprilate
Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.
Product Specifications
CAS Number
89371-44-8
Product Name Alternative
6366A; Imidaprilat
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Imidaprilate.html
Purity
96.64
Solubility
10 mM in DMSO
Smiles
O=C([C@H](CN1C)N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)C1=O)O
Molecular Formula
C18H23N3O6
Molecular Weight
377.39
References & Citations
[1]Kubo M, et al. Pharmacological studies on (4S) -1-methyl-3-[ (2S) -2-[N- ((1S) -1-ethoxycarbonyl-3-phenylpropyl) amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Jpn J Pharmacol. 1990 Jun;53 (2) :201-10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
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