Imidaprilate

Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease.

Product Specifications

CAS Number

[89371-44-8]

Product Name Alternative

6366A; Imidaprilat

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Imidaprilate.html

Purity

96.64

Solubility

10 mM in DMSO

Smiles

O=C([C@H](CN1C)N(C([C@@H](N[C@H](C(O)=O)CCC2=CC=CC=C2)C)=O)C1=O)O

Molecular Formula

C18H23N3O6

Molecular Weight

377.39

References & Citations

[1]Kubo M, et al. Pharmacological studies on (4S) -1-methyl-3-[ (2S) -2-[N- ((1S) -1-ethoxycarbonyl-3-phenylpropyl) amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Jpn J Pharmacol. 1990 Jun;53 (2) :201-10.