TTA-P1
TTA-P1 is a potent state-independent compound inhibiting human T-type calcium channel. T-type calcium channels play a role in diverse physiological responses including neuronal burst firing, hormone secretion, and cell growth. TTA-P1 has the potential for the research of absence epilepsy[1].
Product Specifications
CAS Number
918333-06-9
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tta-p1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(C(NC[C@H]2CCN(CCC(C)(C)C)C[C@H]2F)=O)=CC(Cl)=C1
Molecular Formula
C19H27Cl2FN2O
Molecular Weight
389.33
References & Citations
[1]Uebele VN, Nuss CE, Fox SV, et al. Positive allosteric interaction of structurally diverse T-type calcium channel antagonists. Cell Biochem Biophys. 2009;55 (2) :81-93.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
T-type calcium channel
Frequently Asked Questions
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