Isopropyl unoprostone

Isopropyl unoprostone (Unoprostone isopropyl ester), an analogue of a prostaglandin metabolite, is a potent large conductance Ca2+-activated K+ (BK) channels activator. Isopropyl unoprostone has antiglaucoma effects, lowering intraocular pressure (IOP) by increasing aqueous humour outflow. Isopropyl unoprostone can improve retinal sensitivity and the protection of central retinal sensitivity[1][2].

Product Specifications

CAS Number

[120373-24-2]

Product Name Alternative

Unoprostone isopropyl ester; UF-021

UNSPSC

12352211

Hazard Statement

H225, H302, H319, H336

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/isopropyl-unoprostone.html

Concentration

23.55 mM * 100 μL in Methyl acetate

Purity

95.10

Solubility

10 mM in DMSO

Smiles

O=C(OC(C)C)CCC/C=C\C[C@@H]1[C@@H](CCC(CCCCCCC)=O)[C@H](O)C[C@@H]1O

Molecular Formula

C25H44O5

Molecular Weight

424.61

Precautions

H225, H302, H319, H336

References & Citations

[1]Haria M, et al. Unoprostone (isopropyl unoprostone) . Drugs Aging. 1996 Sep;9 (3) :213-8; discussion 219-20. |[2]Tsuruma K, et al. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels. Mol Vis. 2011;17:3556-65.