Fosifidancitinib

Fosifidancitinib is a potent and selective inhibitor of JAK kinases 1/3. Fociatinib is used in studies of allergies, asthma and autoimmune diseases[1].

Product Specifications

CAS Number

[1237168-58-9]

UNSPSC

12352005

Hazard Statement

H319-H362-H413

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/fosifidancitinib.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=CC=C(NC3=NC(NC4=CC(C)=C(F)C(OC)=C4)=NC=C3C)C=C2N1COP(O)(O)=O

Molecular Formula

C21H21FN5O7P

Molecular Weight

505.39

Precautions

P260-P263-P264-P270-P273-P280-P305+P351+P338-P501

References & Citations

[1]Li, Hui; Heckrodt, Thilo J.; Chen, Yan; Mcmurtrie, Darren John; Taylor, Vanessa; Singh, Rajinder; Ding, Pingyu; Yen, Rose.Preparation of phenylaminopyrimidinylaminooxobenzooxazole derivatives for use as JAK kinase inhibitors. WO2012015972A1