Opiranserin
Opiranserin (VVZ-149), a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin shows antagonistic activity on rP2X3 (IC50=0.87 μM) . Opiranserin is development as an injectable agent for the treatment of postoperative pain[1][2][3].
Product Specifications
CAS Number
1441000-45-8
Product Name Alternative
VVZ-149
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor; GlyT; P2X Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/opiranserin.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OC)=C(OCCCC)C(OC)=C1)NCC2(CCOCC2)N(C)C
Molecular Formula
C21H34N2O5
Molecular Weight
394.51
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT2 Receptor; GlyT2; P2X3 Receptor; α-1 microglobulin
Frequently Asked Questions
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