Enarodustat (hydrochloride)
Enarodustat hydrochloride is a potent and orally active HIF/HIF Prolyl-Hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat hydrochloride has the potential for renal anemia treatment.
Product Specifications
CAS Number
1262131-60-1
Product Name Alternative
JTZ-951 (hydrochloride) ; SAL0951 (hydrochloride)
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/enarodustat-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C1=NC=NN1C(CCC2=CC=CC=C2)=C3)=C3O)NCC(O)=O.Cl
Molecular Formula
C17H17ClN4O4
Molecular Weight
376.79
References & Citations
[1]Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8 (12) :1320-1325.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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